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Guide to Skin Medications

List of Medications That May Stain or Damage Clothing

Revised 07/30/2024

Updates to this list should be requested by submitting the name and dosage of skin medication (oitments, creams, lotions, etc.) via PSAS Benefits mailgroup at: vhapsasbenefits@va.gov

NAME OF MEDICATION  YES or NO GENERIC/BRAND NAMES/COMMENTS: 
A&D OINTMENT NO  
ABSORBASE NO  
ACETONE/BASIC FUCHSIN/BORIC ACID/RESORCINOL TOP LIQ YES  
ACITRETIN (SORIATONE)  NO  
ACYCLOVIR 5% OINT YES  
ADAPALENE 1% TOP CREAM NO  
ADAPALENE 1% TOP GEL NO  
ALUMINUM HEXAHYDRATE 20% TOP SOLN YES DRYSOL, HYPERCARE, XERAC AC 
AMICINONIDE 0.1% CREAM NO  
AMITRIPTYLINE NO blue/blue green urine discoloration 
AMMONIUM LACTATE 12% LOTION NO lac-hydrin
AMPTHOTERICIN B, TOPICAL  YES Fungizone 
ANTHRALIN 1% CREAM YES Dritho-Scalp, Psoriatec 
APEXI-CON E Cream NO Diflorasone diacetate cream 0.05% emollient 
APOMORPHINE YES Apokyn 
AZELAIC ACID 15% NO  
BACITRACIN 500/POLYMIXYIN 1000/GM OINT YES due to polymyxin component
BACITRACIN 500UNT/GM TOP OINT NO  
BACITRACIN/NEOMYCIN/POLYMYXIN TOP OINT YES due to polymyxin component
BECALPERMIN 0.01% TOP GEL NO  
BENOXINATE HCL/FLUORESCEIN NA YES  
BENZOYL PEROXIDE 10% (WATER BASED) GEL YES  
BENZOYL PEROXIDE 2.5% TOP GEL YES  
BENZOYL PEROXIDE 5% (ALCOHOL BASED) GEL YES bleach hair or clothes
BENZOYL PEROXIDE 5% WASH YES  
BETAMETHASONE DIPRO AUGMENT 0.05 OINT NO  
BETAMETHASONE DIPROPIONATE 0.05% CREAM NO  
BETAMETHASONE DIPR 0.05/CLOTRIM 1% CREAM NO lotrisone
BETAMETHASONE VALERATE 0.1% OINT NO  
BIAFINE TOP EMULSION NO  
BISMUTH NO yellow/brwn urine discoloration 
BODY (KERI) LOT 2OZ. BT NO  
CADEXOMER IODINE 0.9% TOP GEL NO  
CALAMINE LOTION NO  
CALCIPOTRIENE 0.005% TOP CREAM YES Dovonex
CALCIPOTRIENE 0.005% TOL SOLN YES Dovonex
CALCITRIOL (VECTICAL) NO has petrolatum but can be removed through usual laundering
CALMOSEPTINE OINT NO  
CAMPHOR 0.5/MENTHOL 0.5% LOTION NO Sarna 
CAPSAICIN 0.025% CREAM NO  
CAPSAICIN 0.075% CREAM NO  
CASTELLANI COLORLESS TOP PAINT YES stains clothes and skin
CASCARA  NO  
CASTOR OIL/PERUVIAN BALSAM/TRYPSIN OINT NO  
CETAPHIL (w/o SPF) NO  
CETAPHIL (w/ SPF) NO  
CETIRZINE  NO  
CHLORHEXIDINE GLUCONATE LIQUID, Topical  YES  
CHLOROQUINE PHOSPHATE  NO yellow/brwn urine discoloration 
CHLORZOXAZONE NO orange/yellow urine discoloration 
CICLOPIROX 8% TOP SOLN YES  
CICLOPIROX OLAMINE 0.77% CREAM NO  
CLINDAMYCIN PHOSPHATE 1% LOTION NO  
CLINDAMYCIN PHOSPHATE 1% TOP SOLN NO  
CLIOQUINOL  YES  
CLOBETASOL PROPIONATE 0.05% CREAM NO  
CLOBETASOL PROPIONATE 0.05% OINT NO   
CLOBETASOL PROPIONATE 0.05% TOP FOAM NO  
CLOBETASOL PROPIONATE 0.05% TOP SOLUTIONS NO  
CLOBETASOL PROPIONATE 1% or greater  YES Temorate; Olux 
CLOBEX LOTION NO  
CLOFAZIMINE NO   
CLOTRIMAZOLE 1% TOP CREAM NO  
CLOTRIMAZOLE 1% TOL SOLN NO  
CLOTRIMAZOLE/BETAMETHASONE  NO lotrisone
COAL TAR 1% SHAMPOO YES stains hair, skin, clothing
COAL TAR 2%/LANOLIN/MINERAL OIL YES stains hair, skin, clothing
COAL TAR 2.5% TOP SOLN YES stains hair, skin, clothing
COAL TAR 5% GEL TOPICAL 5% YES stains hair, skin, clothing
COLLAGENASE 250UNT/GM TOP OINT NO  
COCOA BUTTER OINT NO  
CORN STARCHTOP PWD NO  
CROTAMINTON 10% TOP CREAM YES ** brand eurax is non-staining
DAPSONE 5% TOP GEL NO  
DAUNORUBICIN  NO red/pink urine discoloration 
DEFERIPRONE NO  
DERMA CERIN TOP CREAM NO  
DESONIDE 0.05% CREAM NO  
DESONIDE 0.05% OINT NO  
DEXAMETHASONE  NO  
DIBUCAINE 1% OINT NO nupercainal
DICLOFENAC GEL NO  
DIHYDROERGOTAMINE NO orange/yellow urine discoloration 
DIMETHICONE 1% TOP OINT NO  
DIPHENHYDRAMINE (Oral)  NO  
DOMEBORO (powder packets)  YES  
DOXEPIN HCL 5% TOP CREAM NO Sinequan 
DOXORUBICIN NO red/pink urine discoloration 
DRYSOL 20% SOLN YES  
EFLORNITHINE HCL 13.9% CREAM NO vaniqa
EMUL OINT MENTHOL 1/2% PHENOL 1/8% NO  
EMUL OINT MENTHOL 1/4% (OZ) NO  
ERYTHROMYCIN 2% TOP PAD NO   
ERYTHROMYCIN 2% TOP SOLN NO  
ETHYL CHLORIDE TOP SPRAY NO  
EUCERIN EMUL OINT MENTHOL 1/4%/PHENOL 1/8% NO  
EUCERIN EMULSION OINT WITH 1/2% MENTHOL NO  
EUCERIN W/MENTHOL 1/4% EMUL OINT MENTHOL 1/4% NO  
EUCERIN EMUL OINT MENTHOL 1/2%/PHENOL 1/8% NO  
EURAX 5% Cream (60ml) NO  
FAMCICLOVIR (FAMVIR)  NO  
FERROUS SALTS (IRON DEXTRAN) NO dark brwn urine discoloration 
FLUOCIN 0.01/H-QUIN 4/TRENTIN 0.05 NO  
FLUOCINONIDE 0.05% TOP SOLN NO  
FLUOCINOLONE ACETONIDE 0.01% TOP OIL NO  
FLUOCINOLONE ACETONIDE 0.01% TOP SOLN NO  
FLUOCINOLONE ACETONIDE 0.01% NO capex
FLUOCINONIDE 0.05% CREAM NO lidex
FLUOCINONIDE 0.05% OINT NO lidex
FLUOCINONIDE 0.05% TOP GEL NO lidex
FLUORESCEIN OPTHALMIC YES  
FLUORESCEIN NA/PROPARACAINE YES  
FLUOROUACIL 2% TOP SOLN NO FLOUROPLEX; EFUDEX 
FLUOROURACIL 5% CREAM NO  
FLURANDRENOLIDE 4MCG/SQCM TAPE 24IN ROLL NO  
FLUOROURACIL 1% CREAM NO  
Fluticasone Propionate Cream 0.05% NO Drying agent 
GENTIAN VIOLET 2% TOP SOLN NO  
GLYCOLIC ACID 12% LOTION NO  
HALCINONIDE 0.1% CREAM NO  
HALOBETASOL YES  
HEPARIN NO orange/yellow urine discoloration 
HIBICLENS  NO chlorhexidine gluconate
HYDROCORTISONE 0.5% CREAM NO  
HYDROCORTISONE 1% OINT NO  
HYDROCORTISONE 1% LOTION NO  
HYDROCORTISONE 2.5% OINT NO  
HYDROCORTISONE BUTYRATE 0.1% EMOL NO  
HYDROPHILIC NO  
HYDROPHILIC OINT/AQUAPHOR 50/50 NO  
HYDROPHOR/MENTHOL 0.1%/PHENOL 0.1% NO  
HYDROQUINONE 3.3% TOP SOLN YES  
HYDROQUINONE 4% CREAM YES  
HYDROQUINONE 4/PADIMATE-O 3% CREAM YES  
HYDROXYCHLOROQUINE (PLAQUENIL SULFATE)  NO  
KETOCONAZOLE 2% CREAM NO  
KETOCONTAZOLE 2% SHAMPOO NO  
IODOQUINOL NO underwear staining 
ISOTRETINOIN (10mg, 20mg, 40mg oral caps) NO ACCUTANE 
LEVODOPA  NO dark brwn urine discoloration 
LIDEX OINTMENT 2.5% NO  
LIDOCAINE HCL 2% TOP JELLY NO  
LIDOCAINE 5% OINT NO  
LIDOCAINE PATCHES NO  
LINDANE 1% (KWELL) YES HEXACHCLOROCYCLOHEXANE 
LORATADINE  NO  
LUBRICATING TOP JELLY BACTERIOSTATIC NO  
LUBRIDERM NO  
MENTHOL 10%/METHYL SALICYLATE 15% CREAM NO  
MENTHOL 10%/METHYLSALICYLATE 30% TOP CR NO  
MESALAMINE SUPPOSITORY YES  
METHOCARBAMOL  NO   
METHOTREXATE  NO  
METHYLENE BLUE  NO blue/blue green urine discoloration 
METRONIDAZOLE 0.75% TOP GEL NO  
METHYLDOPA  NO dark brwn urine discoloration 
MICONAZOLE NITRATE 2% TOP POWDER NO  
MIMYX TOPICAL CREAM NO  
MINOCYCLINE (HYDROCHLORIDE) YES  
MINOCYCLINE (50mg, 100mg oral caps) NO  
MITOXANTRONE  NO  
MOMETASONE FUROATE CREAM NO Elocon Oitment, Cream, Lotion; Asmanex 
MUPIROCIN 2% OINT YES  
MUSTARGEN 2.5MG% IN 1000GM AQUAPHOR NO  
MUSTARGEN 5MG% 1000GM AQUAPHOR NO  
MUSTARGEN 10MG% 1000GM AQUAPHOR NO  
NAFTIFINE HCL 1% CREAM NO  
NITRATES  NO dark brwn urine discoloration 
NITROFURANTOIN NO dark brwn urine discoloration 
NYSTATIN 100000 UNT/GM CREAM NO  
NYSTATIN 100000 UNT/GM TOP PWD NO  
OXSORALEN-ULTRA  NO  
PARA-AMINO BENZOIC ACID (PABA)  YES Sunscreen SPF 30 Lotions 
PENCICLOVIR 1% TOP CREAM NO  
PERIDEX NO chlorhexidine gluconate
PERMETHRIN 1% TOP LOTION NO  
PERMETHRIN 5% CREAM NO  
PETROLATUM (WHITE) OINT NO  
PETROLATUM, WHITE 49.8% PASTE NO  
PETROLATUM/SAL ACID 12% NO  
PHENAZOPYRIDINE NO orange/yellow urine discoloration 
PHENOTHIAZINES  NO red/pink urine discoloration 
PHENYLBUTAZONE NO red/pink urine discoloration 
PHENYTOIN NO red/pink urine discoloration 
PIMECROLIMUS 1% TOP CREAM NO  
PODOFILOX 0.5% TOP SOLN YES condylox
POVIDONE IODINE 10% OINT YES stain removed by iodine stain remover
POVIDONE IODINE 10% TOP SOLN YES stain removed by iodine stain remover
POLYSPORIN OINTMENT NO  
PRAMOXINE (PRAX) NO  
PREDNISONE  NO  
PRIMAQUINE NO yellow/brwn urine discoloration 
PYRVINIUM  NO red if vomiting 
QUININE NO dark brwn urine discoloration 
RIFAMPIN NO orange/yellow urine discoloration 
ROSE BENGAL SODIUM OPTHALMIC YES  
SALICYLATES  NO red/pink urine discoloration 
SALICYLIC ACID 17% SOLN, TOP NO  
SALICYLIC ACID 2/SULFUR 2% SHAMPOO NO  
SALICYLIC ACID 3% TOP GEL NO  
SALICYLIC ACID 6% SHAMPOO NO  
SELENIUM SULFIDE 2.5% LOTION/SHAMPOO YES  
SENNA  NO dark brwn urine discoloration 
SILVADENE  NO  
SILVASORB GEL, TOP NO  
SILVER NITRATE YES  
SILVER SULFADIAZINE 1% CREAM NO  
SODIUM HYPOCHLORITE 0.25% TOP SOLN NO  
SODIUM HYPOCHLORITE 0.5% TOP SOLN NO  
SULFACETAMIDE NA 10% LOTION NO  
SULFACETAMIDE NA 10/SULFUR 5% LOTION NO  
SULFASALAZINE  NO orange/yellow urine discoloration 
SULFONAMIDES  NO dark brwn urine discoloration 
SUNSCREEN-30 PABA-FREE COMBINATION LOT NO  
TACROLIMUS 0.03% TOP OINT NO  
TACROLIMUS 0.1% TOP OINT NO  
TAZAROTENE 0.1% TOP GEL NO  
TERBINAFINE HCL 1% CREAM NO  
TETRACAINE HCL COL 2% NO  
TETRACYCLINE OINTMENT YES  
TETRACYCLINE ORAL (250mg, 500mg caps) NO  
TINC OF BENZOIN SPRAY (CN) NO  
TOLUIDINE BLUE NO  blue urine discoloration 
TRETINOIN 0.025% CREAM NO  
TRETINOIN 0.1% CREAM NO  
TRIAMCINOLONE ACETONIDE 0.025% CREAM NO  
TRIAMCINOLONE ACETONIDE 0.025% OINT NO  
TRIAMCINOLONE ACETONIDE 0.1% CREAM NO  
TRIAMCINOLONE ACETONIDE 0.1% LOTION NO  
TRIAMCINOLONE ACETONIDE 0.1% OINT NO  
TRIAMCINOLONE ACETONIDE 0.5% CREAM NO  
TRIAMCINOLONE ACETONIDE 0.5% OINT NO  
TRIAMTERENE NO blue/blue green urine discoloration 
TROLAMINE SALICYLATE 10% LOTION NO  
UREA 10% CREAM NO  
UREA 10% LOTION NO  
UREA 20% CREAM NO  
UREA 40% CREAM NO  
UREA 40% SUSPENSION TOP NO carmol
VANICREAM NO  
VASELINE NO  
WARFARIN NO orange/yellow urine discoloration 
ZINC OXIDE 30.6% TOP CREAM NO  
ZINK PYRITHIONE SHAMPOO NO